DEVELOPMENT OF A CORE OUTCOME SET FOR CONGENITAL PULMONARY AIRWAY MALFORMATIONS: STUDY PROTOCOL OF AN INTERNATIONAL DELPHI SURVEY

Development of a core outcome set for congenital pulmonary airway malformations: study protocol of an international Delphi survey

Introduction A worldwide lack of consensus exists on the optimal management of asymptomatic congenital pulmonary airway malformation (CPAM) even though the incidence is increasing.Either a surgical resection is performed or a wait-and-see policy is employed, depending on the treating physician.Management is largely based on expert opinion and scien

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From individual to herd protection with pneumococcal vaccines: the contribution of the Cuban pneumococcal conjugate vaccine implementation strategy

A new pneumococcal conjugate vaccine is currently undergoing advanced clinical evaluation prior to its planned introduction in Cuba.The implementation of the pneumococcal vaccination strategy has been designed with consideration Music Fridge Magnet of the need to maximize both its direct and indirect effects.A novel approach is suggested, which add

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Mutability and importance of a hypermutable cell subpopulation that produces stress-induced mutants in Escherichia coli.

In bacterial, yeast, and human cells, stress-induced mutation mechanisms are induced in growth-limiting environments and produce non-adaptive and adaptive mutations.These mechanisms may accelerate evolution specifically when cells are maladapted to their environments, i.e., when they are are stressed.One mechanism of stress-induced mutagenesis in E

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